| Synonyms: | MED1, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2 |
| UniProt Protein Function: | MED1: a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. Also is a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. May regulates p53-dependent apoptosis. Is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 17q12 Cellular Component: chromatin; membrane; nucleolus; nucleoplasm; nucleus; Srb-mediator complex; ubiquitin ligase complex Molecular Function:chromatin binding; chromatin DNA binding; estrogen receptor binding; LBD domain binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; receptor activity; retinoic acid receptor binding; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription cofactor activity; transcription factor binding; vitamin D receptor binding Biological Process: androgen biosynthetic process; androgen receptor signaling pathway; angiogenesis; brain development; cell morphogenesis; cellular lipid metabolic process; embryonic heart tube development; embryonic hemopoiesis; embryonic hindlimb morphogenesis; embryonic placenta development; enucleate erythrocyte development; erythrocyte development; fat cell differentiation; gene expression; keratinocyte differentiation; lactation; lens development in camera-type eye; liver development; monocyte differentiation; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; organ regeneration; positive regulation of erythrocyte differentiation; positive regulation of estrogen receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein ubiquitination; regulation of cell cycle; regulation of transcription from RNA polymerase I promoter; steroid hormone receptor signaling pathway; thyroid hormone generation; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15648 |
| NCBI GenInfo Identifier: | 158518535 |
| NCBI Gene ID: | 5469 |
| NCBI Accession: | Q15648.4 |
| UniProt Secondary Accession: | Q15648,O43810, O75447, Q6P9H7, Q6PK58, Q9HD39, A2RRQ6 |
| UniProt Related Accession: | Q15648 |
| Molecular Weight: | 61,563 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 1 |
| NCBI Synonym Full Names: | mediator complex subunit 1 |
| NCBI Official Symbol: | MED1 |
| NCBI Official Synonym Symbols: | PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220 |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 1 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 1 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Trap220; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; Vitamin D receptor-interacting protein complex component DRIP205; p53 regulatory protein RB18A |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED1 |
| UniProt Entry Name: | MED1_HUMAN |
