KO Validated Antibodies 2
Anti-MDH2 Antibody (CAB19906)[KO Validated]
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![Anti-MDH2 Antibody (CAB19906)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/56076/61258/anti-mdh2-antibody-cab19906ko-validated__22855__47262.1706533752.jpg?c=1 "Anti-MDH2 Antibody (CAB19906)[KO Validated]")
- SKU:
- CAB19906
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
![Anti-MDH2 Antibody (CAB19906)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/56076/61258/anti-mdh2-antibody-cab19906ko-validated__22855__47262.1706533752.jpg?c=1&imbypass=on "Anti-MDH2 Antibody (CAB19906)[KO Validated]")
Description
| Antibody Name: | Anti-MDH2 Antibody [KO Validated] |
| Antibody SKU: | CAB19906 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MDH2. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human MDH2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4191 |
| Uniprot: | P40926 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 30kDa/35kDa |
| Observed MW: | 37KDa |
![Anti-MDH2 Antibody [KO Validated] (CAB19906)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/t/901/A19906_1__59140.jpg) | Western blot analysis of extracts from normal (control) and MDH2 knockout (KO) 293T cells, using MDH2 antibody (CAB19906) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
| Synonyms: | MDH2, EIEE51, M-MDH, MDH, MGC:3559, MOR1 |
| Background: | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MDH2: mitochondrial malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. May play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 1.1.1.37; Oxidoreductase Chromosomal Location of Human Ortholog: 7cen-q22 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; plasma membrane; nucleus Molecular Function:protein self-association; L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity Biological Process: cellular metabolic process; malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; pathogenesis; cellular carbohydrate metabolic process; internal protein amino acid acetylation; gluconeogenesis |
| NCBI Summary: | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P40926 |
| NCBI GenInfo Identifier: | 215274114 |
| NCBI Gene ID: | 4191 |
| NCBI Accession: | P40926.3 |
| UniProt Secondary Accession: | P40926,O43682, A8K414, B2RE78, B4DE44, E9PDB2, |
| UniProt Related Accession: | P40926 |
| Molecular Weight: | 338 |
| NCBI Full Name: | Malate dehydrogenase, mitochondrial |
| NCBI Synonym Full Names: | malate dehydrogenase 2, NAD (mitochondrial) |
| NCBI Official Symbol: | MDH2 |
| NCBI Official Synonym Symbols: | MDH; MOR1; M-MDH; MGC:3559 |
| NCBI Protein Information: | malate dehydrogenase, mitochondrial |
| UniProt Protein Name: | Malate dehydrogenase, mitochondrial |
| Protein Family: | Malate dehydrogenase |
| UniProt Gene Name: | MDH2 |
| UniProt Entry Name: | MDHM_HUMAN |
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