Cell Death Antibodies 1

MCL1 Rabbit Polyclonal Antibody (CAB0250)

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SKU:
CAB0250
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse
Synonyms:
TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT, MCL1
Research Use:
Cell Death
Frequently bought together:

Description

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MCL1 Antibody (CAB0250)

The MCL1 Antibody (CAB0250) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MCL1 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in cancer research and cell biology.MCL1, a member of the Bcl-2 family of proteins, plays a crucial role in controlling cell survival and resistance to apoptosis. Its dysregulation is often associated with cancer development and progression, making it an important target for therapeutic interventions.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:MCL1 Antibody
SKU:CAB0250
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:SGNN TSTD GSLP STPP PAEE EEDE LYRQ SLEI ISRY LREQ ATGA KDTK PMGR SGAT SRKA LETL RRVG DGVQ RNHE TAFQ GMLR KLDI KNED DVKS LSRV M
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT, MCL1
Positive Sample:BT-474, Raji, Mouse lung, Mouse thymus
Cellular Localization:Cytoplasm, Membrane, Mitochondrion, Nucleus, Single-Pass Membrane Protein, Nucleoplasm.
Calculated MW:37kDa
Observed MW:37kDa

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Purification MethodAffinity purification
Gene ID4170
RRIDAB_2757063
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using MCL1 Rabbit pAb (CAB0250) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse brain using MCL1 Rabbit pAb (CAB0250) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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