Cell Biology Antibodies 12

MAN2B1 Rabbit Polyclonal Antibody (CAB9937)

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SKU:
CAB9937
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Synonyms:
MANB, LAMAN, MAN2B1
Research Use:
Cell Biology
Frequently bought together:

Description

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MAN2B1 Antibody (CAB9937)

The MAN2B1 Antibody (CAB9937) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.MAN2B1 is involved in the breakdown of complex carbohydrates within lysosomes, making it critical for cellular function and metabolism. Dysregulation of MAN2B1 activity has been linked to lysosomal storage disorders and other diseases, making it an important target for research in the fields of biochemistry and molecular biology.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse samples.

Product Name:MAN2B1 Antibody
SKU:CAB9937
Size:20μL, 100μL
Reactivity:Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:TFFW YNAS IGDN ESDQ ASGA YIFR PNQQ KPLP VSRW AQIH LVKT PLVQ EVHQ NFSA WCSQ VVRL YPGQ RHLE LEWS VGPI PVGD TWGK EVIS RFDT PLET KGRF YTDS NGRE ILER RRDY RPTW KLNQ TEPV AGNY YPVN TRIY ITDG NMQL TVLT DRSQ GGSS LRDG SLEL MVHR RLLK DDGR GVSE PLME NGSG AWVR GRHL VLLD TAQ
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MANB, LAMAN, MAN2B1
Positive Sample:Mouse liver
Cellular Localization:Lysosome.
Calculated MW:114kDa
Observed MW:170kDa

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID4125
RRIDAB_2770256
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from mouse liver, using MAN2B1 Rabbit pAb (CAB9937) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
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