Epigenetics & Nuclear Signaling Antibodies 5

LOXL2 Rabbit Monoclonal Antibody (CAB4708)

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SKU:
CAB4708
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Synonyms:
LOR, LOR2, WS9-14, LOXL2
Research Use:
Epigenetics and Nuclear Signaling
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Description

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LOXL2 Monoclonal Antibody (CAB4708)

The LOXL2 Monoclonal Antibody (CAB4708) is a high-quality antibody developed for reliable detection and analysis of target proteins. This highly specific antibody, developed using rabbit monoclonal technology, shows exceptional reactivity with human samples and is validated for use in various experimental techniques, including Western blotting.LOXL2, a member of the lysyl oxidase family, plays a crucial role in tissue development and homeostasis by catalyzing the cross-linking of collagen and elastin fibers. Dysregulation of LOXL2 has been implicated in various diseases, including fibrosis, cancer, and cardiovascular disorders.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:LOXL2 Monoclonal Antibody
SKU:CAB4708
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC1100
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:NFGD QGIT MGCW DMYR HDID CQWV DITD VPPG DYLF QVVI NPNF EVAE SDYS NNIM KCRS RYDG HRIW MYNC HIGG SFSE ETEK KFEH FSGL LNNQ LSPQ
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:LOR, LOR2, WS9-14, LOXL2
Positive Sample:A-549, PC-3
Cellular Localization:Chromosome, Nucleus, Secreted, Basement Membrane, Extracellular Matrix, Extracellular Space.
Calculated MW:87kDa
Observed MW:100kDa

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Purification MethodAffinity purification
Gene ID4017
RRIDAB_2863328
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using LOXL2 Rabbit mAb (CAB4708) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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