Anti-Kir6.1 Antibody [N366/60 (Formerly sold as S366-60)]

Kir6.1 Antibody [N366/60 (Formerly sold as S366-60)]

Kir6.1 Antibody [N366/60 (Formerly sold as S366-60)] is a mouse monoclonal antibody directed against Kir6.1, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2A, purified by Protein G.

Kir6.1, encoded by the KCNJ8 gene, is a member of the inwardly rectifying potassium (Kir) channel family, which plays a critical role in regulating membrane potential and cellular excitability. Unlike voltage-gated potassium channels, Kir channels preferentially allow potassium ions to flow into the cell, stabilizing the resting membrane potential and modulating neuronal responsiveness. Kir6.1 is a key subunit of ATP-sensitive potassium (K_ATP) channels, which couple cellular metabolic state to electrical activity. While Kir6.1 is predominantly expressed in cardiac and smooth muscle tissues—including fetal and adult hearts—it is also present in the brain, where it contributes to neurovascular coupling and neuronal protection under metabolic stress. In the nervous system, Kir6.1-containing K_ATP channels are activated during conditions of energy depletion, such as ischemia or oxidative stress, helping to hyperpolarize neurons and reduce excitotoxicity. Dysregulation of Kir6.1 function has been implicated in neurodegenerative diseases, including stroke, Alzheimer’s disease, and Parkinson’s disease, where impaired energy metabolism and ionic imbalance are central pathological features. Furthermore, mutations in KCNJ8 have been associated with J-wave syndromes and other channelopathies, highlighting the broader physiological importance of Kir6.1 in excitable tissues. As research into metabolic regulation and ion channel dysfunction in neurodegeneration advances, Kir6.1 is emerging as a promising target for therapeutic intervention aimed at preserving neuronal function and preventing cell death. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.