Cell Biology Antibodies 12
Anti-Kallikrein-8 Antibody (CAB8975)
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- SKU:
- CAB8975
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Kallikrein-8 Antibody |
| Antibody SKU: | CAB8975 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-200 of human KLK8 (NP_009127.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SKOV3, U-87MG, A-431, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-200 of human KLK8 (NP_009127.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLGG HECQ PHSQ PWQA ALFQ GQQL LCGG VLVG GNWV LTAA HCKK PKYT VRLG DHSL QNKD GPEQ EIPV VQSI PHPC YNSS DVED HNHD LMLL QLRD QASL GSKV KPIS LADH CTQP GQKC TVSG WGTV TSPR ENFP DTLN CAEV KIFP QKKC EDAY PGQI TDGM VCAG |
| Gene ID: | 11202 |
| Uniprot: | O60259 |
| Cellular Location: | Cytoplasm, Secreted |
| Calculated MW: | 3kDa/12kDa/28kDa/32kDa |
| Observed MW: | 28kDa |
| Synonyms: | KLK8, HNP, NP, NRPN, PRSS19, TADG14 |
| Background: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | KLK8: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.118; Cell development/differentiation; Secreted; Protease Chromosomal Location of Human Ortholog: 19q13 Cellular Component: cytoplasm; extracellular space Molecular Function:protein binding; serine-type endopeptidase activity Biological Process: cell death; keratinocyte proliferation; memory; negative regulation of axon regeneration; negative regulation of myelination; neurite morphogenesis; regulation of synapse organization and biogenesis; response to wounding |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O60259 |
| NCBI GenInfo Identifier: | 6093536 |
| NCBI Gene ID: | 11202 |
| NCBI Accession: | O60259.1 |
| UniProt Secondary Accession: | O60259,Q5V9X1, Q5V9X2, Q8IW69, Q9HCB3, Q9NR68, Q9NR69 Q9UIL9, Q9UQ47, |
| UniProt Related Accession: | O60259 |
| Molecular Weight: | 3,653 Da |
| NCBI Full Name: | Kallikrein-8 |
| NCBI Synonym Full Names: | kallikrein related peptidase 8 |
| NCBI Official Symbol: | KLK8 |
| NCBI Official Synonym Symbols: | NP; HNP; NRPN; PRSS19; TADG14 |
| NCBI Protein Information: | kallikrein-8 |
| UniProt Protein Name: | Kallikrein-8 |
| UniProt Synonym Protein Names: | Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK8 |
| UniProt Entry Name: | KLK8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLK8 antibody (CAB8975) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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