Cell Biology Antibodies 13
Anti-INPP5E Antibody (CAB17735)
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- SKU:
- CAB17735
Description
| Antibody Name: | Anti-INPP5E Antibody |
| Antibody SKU: | CAB17735 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LIRE MRKG SIFK GFQE PDIH FLPS YKFD IGKD TYDS TSKQ RTPS YTDR VLYR SRHK GDIC PVSY SSCP GIKT SDHR PVYG LFRV KVRP GRDN IPLA AGKF DREL YLLG IKRR ISKE IQRQ Q |
| Gene ID: | 56623 |
| Uniprot: | Q9NRR6 |
| Cellular Location: | |
| Calculated MW: | 66kDa/70kDa |
| Observed MW: | 80kDa |
 | Western blot - INPP5E Polyclonal Antibody (CAB17735) |
| Synonyms: | CORS1, CPD4, JBTS1, MORMS, PPI5PIV, pharbin, INPP5E |
| Background: | The protein encoded by this gene is an inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1, 4, 5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3, 4, 5-trisphosphate and phosphatidylinositol 3, 5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Protein Function: | Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. |
| NCBI Summary: | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9NRR6 |
| NCBI GenInfo Identifier: | 972781524 |
| NCBI Gene ID: | 56623 |
| NCBI Accession: | NP_001305431.1 |
| UniProt Secondary Accession: | Q9NRR6,Q15734, Q6PIV5, |
| UniProt Related Accession: | Q9NRR6 |
| Molecular Weight: | 70 |
| NCBI Full Name: | 72 kDa inositol polyphosphate 5-phosphatase isoform 2 |
| NCBI Synonym Full Names: | inositol polyphosphate-5-phosphatase E |
| NCBI Official Symbol: | INPP5E |
| NCBI Official Synonym Symbols: | CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin |
| NCBI Protein Information: | 72 kDa inositol polyphosphate 5-phosphatase |
| UniProt Protein Name: | 72 kDa inositol polyphosphate 5-phosphatase |
| UniProt Synonym Protein Names: | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV |
| UniProt Gene Name: | INPP5E |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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