| Background: | This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | 5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q36.3-q37.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:drug binding; G-protein alpha-subunit binding; GTPase activator activity; serotonin binding; serotonin receptor activity Biological Process: calcium-mediated signaling; cellular calcium ion homeostasis; cGMP biosynthetic process; embryonic morphogenesis; G-protein coupled receptor protein signaling pathway; heart morphogenesis; intestine smooth muscle contraction; negative regulation of apoptosis; negative regulation of autophagy; neural crest cell differentiation; neural crest cell migration; phosphoinositide 3-kinase cascade; phospholipase C activation; phosphorylation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C activation; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; vasoconstriction |
| NCBI Summary: | This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P41595 |
| NCBI GenInfo Identifier: | 1168220 |
| NCBI Gene ID: | 3357 |
| NCBI Accession: | P41595.1 |
| UniProt Secondary Accession: | P41595,Q53TI1, Q62221, Q6P523, B2R9D5, |
| UniProt Related Accession: | P41595,AAB31827 |
| Molecular Weight: | 54,298 Da |
| NCBI Full Name: | 5-hydroxytryptamine receptor 2B |
| NCBI Synonym Full Names: | 5-hydroxytryptamine receptor 2B |
| NCBI Official Symbol: | HTR2B |
| NCBI Official Synonym Symbols: | 5-HT2B; 5-HT-2B; 5-HT(2B) |
| NCBI Protein Information: | 5-hydroxytryptamine receptor 2B |
| UniProt Protein Name: | 5-hydroxytryptamine receptor 2B |
| UniProt Synonym Protein Names: | Serotonin receptor 2B |
| UniProt Gene Name: | HTR2B |
| UniProt Entry Name: | 5HT2B_HUMAN |
