Anti-HOMER1 Antibody (CAB4302)

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SKU:
CAB4302

Description

Product Name:HOMER1 Rabbit pAb
Product Code:CAB4302
Size:100uL
Synonyms:HOMER1, HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human HOMER1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic Peptide of human HOMER1
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9456
Uniprot:Q86YM7
Cellular Location:Cell junction, Cytoplasm, postsynaptic cell membrane, postsynaptic density, synapse
Calculated MW:19kDa/25kDa/40kDa
Observed MW:Refer to figures
UniProt Protein Function:HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q14.2 Cellular Component: postsynaptic membrane; costamere; cell soma; axon; apical part of cell; excitatory synapse; dendritic shaft; Z disc; cell junction Molecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffold Biological Process: skeletal muscle contraction; circadian rhythm; response to nicotine; synaptic transmission; positive regulation of signal transduction; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
UniProt Code:Q86YM7
NCBI GenInfo Identifier:38604765
NCBI Gene ID:9456
NCBI Accession:Q86YM7.2
UniProt Secondary Accession:Q86YM7
UniProt Related Accession:Q86YM7
Molecular Weight:
NCBI Full Name:Homer protein homolog 1
NCBI Synonym Full Names:homer scaffold protein 1
NCBI Official Symbol:HOMER1  
NCBI Official Synonym Symbols:HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C  
NCBI Protein Information:homer protein homolog 1
UniProt Protein Name:Homer protein homolog 1
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:HOMER1  
UniProt Entry Name:HOME1_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HOMER1
Synonyms:
HOMER
Synonyms:
HOMER1A
Synonyms:
HOMER1B
Synonyms:
HOMER1C
Synonyms:
SYN47
Synonyms:
Ves-1
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