Cell Biology Antibodies 13

Anti-HNRPAB Antibody (CAB17497)

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SKU:
CAB17497
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:HNRPolyclonal Antibody Rabbit Polyclonal Antibody
Antibody SKU:CAB17497
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human HNRPAB (NP_004490.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human HNRPAB (NP_004490.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSEA GEEQ PMET TGAT ENGH EAVP EGES PAGA GTGA AAGA GGAT AAPP SGNQ NGAE GDQI NASK NEED AGKM FVGG LSWD TSKK DLKD YFTK FGEV VDCT IKMD PNTG RSRG FGFI LFKD AASV EKVL DQKE HRLD GRVI DPKK AMAM KKDP VKKI FVGG LNPE ATEE KIRE YFGE FGEI EAIE LPMD PKLN KRRG FVFI TFKE EEPV KKVL EKKF HTVS GSKC EIKV AQPK EVYQ QQQY GSGG RGNR NRGN RGSG GGGG GGGQ GSTN YGKS QRRG GHQN NYKP Y
Gene ID:3182
Uniprot:Q99729
Cellular Location:
Calculated MW:
Observed MW:37/41kDa
Anti-HNRPAB Antibody (CAB17497)Western blot - HNRPAB Polyclonal Antibody (CAB17497)
Synonyms:ABBP1, HNRPAB, HNRNPAB
Background:This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:hnRNP A/B: a single-stranded RNA binding protein with two RNA-recognition (RRM) domains. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Interacts with APOBEC1. Observed in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. A member of the RNA recognition motif (RRM) family. Four isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex

Molecular Function:mRNA binding; RNA binding; sequence-specific DNA binding; nucleotide binding; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q99729
NCBI GenInfo Identifier:158523286
NCBI Gene ID:3182
NCBI Accession:Q99729.2
UniProt Related Accession:Q99729
Molecular Weight:
NCBI Full Name:Heterogeneous nuclear ribonucleoprotein A/B
NCBI Synonym Full Names:heterogeneous nuclear ribonucleoprotein A/B
NCBI Official Symbol:HNRNPAB  
NCBI Official Synonym Symbols:ABBP1; HNRPAB  
NCBI Protein Information:heterogeneous nuclear ribonucleoprotein A/B
UniProt Protein Name:Heterogeneous nuclear ribonucleoprotein A/B
UniProt Synonym Protein Names:APOBEC1-binding protein 1
Protein Family:Ribosomal operon-associated A protein
UniProt Gene Name:HNRNPAB  
UniProt Entry Name:ROAA_HUMAN
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