Metabolism Antibodies 2
Anti-HGD Antibody (CAB6618)
- SKU:
- CAB6618
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-HGD Antibody |
| Antibody SKU: | CAB6618 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 226-445 of human HGD (NP_000178.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 226-445 of human HGD (NP_000178.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DFLI PIAW YEDR QVPG GYTV INKY QGKL FAAK QDVS PFNV VAWH GNYT PYKY NLKN FMVI NSVA FDHA DPSI FTVL TAKS VRPG VAIA DFVI FPPR WGVA DKTF RPPY YHRN CMSE FMGL IRGH YEAK QGGF LPGG GSLH STMT PHGP DADC FEKA SKVK LAPE RIAD GTMA FMFE SSLS LAVT KWGL KASR CLDE NYHK CWEP LKSH FTPN SRNP AEPN |
| Gene ID: | 3081 |
| Uniprot: | Q93099 |
| Cellular Location: | |
| Calculated MW: | 49kDa |
| Observed MW: | 50kDa |
| Synonyms: | HGD, AKU, HGO |
| Background: | This gene encodes the enzyme homogentisate 1, 2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria. |
| UniProt Protein Function: | HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.13.11.5; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: 3q13.33 Cellular Component: cytosol Molecular Function:homogentisate 1,2-dioxygenase activity; metal ion binding Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process Disease: Alkaptonuria |
| NCBI Summary: | This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010] |
| UniProt Code: | Q93099 |
| NCBI GenInfo Identifier: | 296434531 |
| NCBI Gene ID: | 3081 |
| NCBI Accession: | Q93099.2 |
| UniProt Secondary Accession: | Q93099,A8K417, B2R8Z0, |
| UniProt Related Accession: | Q93099 |
| Molecular Weight: | 445 |
| NCBI Full Name: | Homogentisate 1,2-dioxygenase |
| NCBI Synonym Full Names: | homogentisate 1,2-dioxygenase |
| NCBI Official Symbol: | HGD |
| NCBI Official Synonym Symbols: | AKU; HGO |
| NCBI Protein Information: | homogentisate 1,2-dioxygenase; homogentisicase; homogentisate oxidase; homogentisate oxygenase; homogentisic acid oxidase |
| UniProt Protein Name: | Homogentisate 1,2-dioxygenase |
| UniProt Synonym Protein Names: | Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase |
| Protein Family: | 2-(hydroxymethyl)glutarate dehydrogenase |
| UniProt Gene Name: | HGD |
| UniProt Entry Name: | HGD_HUMAN |
 | Western blot analysis of extracts of SKOV3 cells, using HGD Antibody (CAB6618) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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