Cell Biology Antibodies 11

GRM4 Rabbit Polyclonal Antibody (CAB7284)

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SKU:
CAB7284
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Mouse, Rat
Synonyms:
mGlu4, GPRC1D, MGLUR4, GRM4
Research Use:
Cell Biology
Frequently bought together:

Description

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GRM4 Antibody (CAB7284)

The GRM4 Antibody (CAB7284) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, demonstrates high reactivity with human GRM4 samples and is validated for use in Western blot applications. By specifically binding to the GRM4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and neuropharmacology.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.

Product Name:GRM4 Antibody
SKU:CAB7284
Size:20μL, 100μL
Reactivity:Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:KPKG HPHM NSIR IDGD ITLG GLFP VHGR GSEG KPCG ELKK EKGI HRLE AMLF ALDR INND PDLL PNIT LGAR ILDT CSRD THAL EQSL TFVQ ALIE KDGT EVRC GSGG PPII TKPE RVVG VIGA SGSS VSIM VANI LRLF KIPQ ISYA STAP DLSD NSRY DFFS RVVP SDTY QAQA MVDI VRAL KWNY VSTV ASEG SYGE SGVE AFIQ KSRE DGGV CIAQ SVKI PREP KAGE FDKI IRRL LETS NARA VIIF ANED DI
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:mGlu4, GPRC1D, MGLUR4, GRM4
Positive Sample:Mouse spinal cord, Rat brain
Cellular Localization:Cell Membrane, Multi-Pass Membrane Protein.
Calculated MW:102kDa
Observed MW:115kDa

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID2914
RRIDAB_2767825
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using GAbGn4 Rabbit pAb (CAB7284) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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