Signal Transduction Antibodies 2

GluR1/GRIA1 Rabbit Polyclonal Antibody (CAB1826)

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SKU:
CAB1826
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
GLUH1, GLUR1, GLURA, GluA1, HBGR1, MRD67, MRT76, GluR1/GRIA1
Research Use:
Signal Transduction
Frequently bought together:

Description

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GluR1/GRIA1 Antibody (CAB1826)

The GluR1/GRIA1 Antibody (CAB1826) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human GRIA1 and has been validated for use in Western blot applications.The AMPA glutamate receptor, which includes the GRIA1 subunit, plays a critical role in synaptic transmission and plasticity, making it essential for learning and memory processes. By targeting the GRIA1 protein, researchers can investigate the function and regulation of AMPA receptors in various neurological disorders, such as Alzheimer's disease, epilepsy, and schizophrenia.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:GluR1/GRIA1 Antibody
SKU:CAB1826
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:PWGQ GIDI QRAL QQVR FEGL TGNV QFNE KGRR TNYT LHVI EMKH DGIR KIGY WNED DKFV PAAT DAQA GGDN SSVQ NRTY IVTT ILED PYVM LKKN ANQF EGND RYEG YCVE LAAE IAKH VGYS YRLE IVSD GKYG ARDP D
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:GLUH1, GLUR1, GLURA, GluA1, HBGR1, MRD67, MRT76, GluR1/GRIA1
Positive Sample:Mouse brain, Rat brain
Cellular Localization:Cell Junction, Cell Membrane, Cell Projection, Endoplasmic Reticulum Membrane, Multi-Pass Membrane Protein, Dendrite, Dendritic Spine, Postsynaptic Cell Membrane, Postsynaptic Density, Synapse.
Calculated MW:102kDa
Observed MW:100kDa

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID2890
RRIDAB_2763863
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using GluR1/GRIA1 Rabbit pAb (CAB1826) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse brain using GluR1/GRIA1 Rabbit pAb (CAB1826) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
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