Cell Biology Antibodies 6

GRAP Rabbit Polyclonal Antibody (CAB15391)

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SKU:
CAB15391
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
DFNB114, GRAP
Research Use:
Cell Biology
Frequently bought together:

Description

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GRAP Antibody (CAB15391)

The GRAP Antibody (CAB15391) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the Grap protein, this antibody enables detection and analysis in various cell types, making it an ideal tool for studies in cancer research and cell biology.Grap is a key player in signaling pathways that regulate cell growth, survival, and migration, making it a promising target for understanding cancer development and progression. Its involvement in pathways related to cell proliferation and survival underscores its potential significance in cancer biology.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:GRAP Antibody
SKU:CAB15391
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LNEL VDFY RTTT IAKK RQIF LRDE EPLL KSPG ACFA QAQF DFSA QDPS QLSF RRGD IIEV LERP DPHW WRGR SCGR VGFF PRSY VQPV HL
Tested Applications:WB ELISA
Recommended Dilution:
WB1:200 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DFNB114, GRAP
Positive Sample:U-251MG, A-549
Cellular Localization:Cytoplasm, Cytosol, Nucleoplasm, Plasma Membrane, Presynapse.
Calculated MW:25kDa
Observed MW:36kDa

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Purification MethodAffinity purification
Gene ID10750
RRIDAB_2762298
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using GRAP Rabbit pAb (CAB15391) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
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