Cell Biology Antibodies 8

Anti-GNA11 Antibody (CAB2731)

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SKU:
CAB2731
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GNA11 Antibody
Antibody SKU:CAB2731
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human GNA11
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, SKOV3, Mouse brain, Mouse kidney, Mouse lung, Mouse intestine
Immunogen:Recombinant protein of human GNA11
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2767
Uniprot:P29992
Cellular Location:Cell membrane, Cytoplasm, Lipid-anchor
Calculated MW:42kDa
Observed MW:42kDa
Synonyms:GNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2
Background:The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.
UniProt Protein Function:G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
UniProt Protein Details:

Protein type:G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function:GTPase activity; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of action potential; platelet activation; metabolic process; heart development; pigmentation during development; dopamine receptor, phospholipase C activating pathway; signal transduction; blood coagulation; skeletal development; regulation of melanocyte differentiation

Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii

NCBI Summary:The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
UniProt Code:P29992
NCBI GenInfo Identifier:3041682
NCBI Gene ID:2767
NCBI Accession:P29992.2
UniProt Related Accession:P29992
Molecular Weight:~42kDa
NCBI Full Name:Guanine nucleotide-binding protein subunit alpha-11
NCBI Synonym Full Names:G protein subunit alpha 11
NCBI Official Symbol:GNA11  
NCBI Official Synonym Symbols:FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2  
NCBI Protein Information:guanine nucleotide-binding protein subunit alpha-11
UniProt Protein Name:Guanine nucleotide-binding protein subunit alpha-11
UniProt Synonym Protein Names:Guanine nucleotide-binding protein G(y) subunit alpha
Protein Family:Guanine nucleotide-binding protein
UniProt Gene Name:GNA11  
UniProt Entry Name:GNA11_HUMAN
Anti-GNA11 Antibody (CAB2731)Western blot analysis of extracts of various cell lines, using GNA11 antibody (CAB2731) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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