Cell Biology Antibodies 9
Anti-GHRH Antibody (CAB5343)
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- SKU:
- CAB5343
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GHRH Antibody |
| Antibody SKU: | CAB5343 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-107 of human GHRH (NP_001171660.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-107 of human GHRH (NP_001171660.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PPPP LTLR MRRY ADAI FTNS YRKV LGQL SARK LLQD IMSR QQGE SNQE RGAR ARLG RQVD SMWA EQKQ MELE SILV ALLQ KHRN SQG |
| Gene ID: | 2691 |
| Uniprot: | P01286 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa |
| Observed MW: | 16KDa |
| Synonyms: | GHRH, GHRF, GRF, INN |
| Background: | This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. |
| UniProt Protein Function: | GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: extracellular space; extracellular region; terminal button Molecular Function:growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01286 |
| NCBI GenInfo Identifier: | 134521 |
| NCBI Gene ID: | 2691 |
| NCBI Accession: | P01286.1 |
| UniProt Secondary Accession: | P01286,Q4KN10, Q5JYR1, |
| UniProt Related Accession: | P01286 |
| Molecular Weight: | 108 |
| NCBI Full Name: | Somatoliberin |
| NCBI Synonym Full Names: | growth hormone releasing hormone |
| NCBI Official Symbol: | GHRH |
| NCBI Official Synonym Symbols: | GRF; INN; GHRF |
| NCBI Protein Information: | somatoliberin; sermorelin; somatorelin; somatocrinin; growth hormone-releasing factor; growth hormone-releasing hormone |
| UniProt Protein Name: | Somatoliberin |
| UniProt Synonym Protein Names: | Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin |
| Protein Family: | Somatoliberin |
| UniProt Gene Name: | GHRH |
| UniProt Entry Name: | SLIB_HUMAN |
 | Western blot analysis of extracts of 293T cells, using GHRH Rabbit pAb (CAB5343) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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