Cell Biology Antibodies 5
Anti-GHR Antibody (CAB14735)
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- SKU:
- CAB14735
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GHR Antibody |
| Antibody SKU: | CAB14735 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-260 of human GHR (NP_001229328.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, Mouse heart, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-260 of human GHR (NP_001229328.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FSGS EATA AILS RAPW SLQS VNPG LKTN SSKE PKFT KCRS PERE TFSC HWTD EVHH GTKN LGPI QLFY TRRN TQEW TQEW KECP DYVS AGEN SCYF NSSF TSIW IPYC IKLT SNGG TVDE KCFS VDEI VQPD PPIA LNWT LLNV SLTG IHAD IQVR WEAP RNAD IQKG WMVL EYEL QYKE VNET KWKM MDPI LTTS VPVY SLKV DKEY EVRV RSKQ RNSG NYGE FSEV LYVT LPQ |
| Gene ID: | 2690 |
| Uniprot: | P10912 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein |
| Calculated MW: | 33kDa/34kDa/69kDa/71kDa |
| Observed MW: | 72kDa |
| Synonyms: | GHR, GHBP, GHIP |
| Background: | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
| UniProt Code: | P10912 |
| NCBI GenInfo Identifier: | 121180 |
| NCBI Gene ID: | 2690 |
| NCBI Accession: | P10912.1 |
| UniProt Secondary Accession: | P10912,Q9HCX2, |
| UniProt Related Accession: | P10912 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Growth hormone receptor |
| NCBI Synonym Full Names: | growth hormone receptor |
| NCBI Official Symbol: | GHR |
| NCBI Official Synonym Symbols: | GHBP |
| NCBI Protein Information: | growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein |
| UniProt Protein Name: | Growth hormone receptor |
| UniProt Synonym Protein Names: | Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein |
| Protein Family: | Ghrelin |
| UniProt Gene Name: | GHR |
| UniProt Entry Name: | GHR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GHR antibody (CAB14735) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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