Epigenetics & Nuclear Signaling Antibodies 1

GEMIN8 Rabbit Polyclonal Antibody (CAB13708)

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SKU:
CAB13708
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Synonyms:
FAM51A1, GEMIN8
Research Use:
Epigenetics and Nuclear Signaling
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Description

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GEMIN8 Antibody (CAB13708)

The GEMIN8 Antibody (CAB13708) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbits as the host species, exhibits high specificity and sensitivity towards Gemin8 in human samples, making it an ideal choice for Western blot applications.Gemin8 plays a pivotal role in various cellular processes, including mRNA export from the nucleus and the assembly of spliceosomal complex. Dysregulation of Gemin8 has been linked to abnormalities in gene expression and RNA metabolism, highlighting its importance in maintaining normal cellular function.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:GEMIN8 Antibody
SKU:CAB13708
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MAAV KAST SKAT RPWY SHPV YARY WQHY HQAM AWMQ SHHN AYRK AVES CFNL PWYL PSAL LPQS SYDN EAAY PQSF YDHH VAWQ DYPC SSSH FRRS GQHP RYSS RIQA STKE DQAL SKEE EMET ESDA EVEC DLSN MEIT EELR QYFA ETER HREE RRRQ QQLD AERL DSYV NADH DLYC NTRR SVEA PTER PGER RQAE MKRL YGDS AAKI QAME AAVQ LSFD KHCD RKQP KYWP VIPL KF
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:FAM51A1, GEMIN8
Positive Sample:A-549, HT-29, HepG2
Cellular Localization:Cytoplasm, Nucleus, Gem.
Calculated MW:29kDa
Observed MW:35kDa

The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.

Purification MethodAffinity purification
Gene ID54960
RRIDAB_2760568
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using GEMIN8 Rabbit pAb (CAB13708) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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