Developmental Biology
Anti-GAP43 Antibody (CAB16857)
- SKU:
- CAB16857
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-GAP43 Antibody |
| Antibody SKU: | CAB16857 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human GAP43 (NP_002036.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | mouse brain, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human GAP43 (NP_002036.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLCC MRRT KQVE KNDD DQKI EQDG IKPE DKAH KAAT KIQA SFRG HITR KKLK GEKK DDVQ AAEA EANK KDEA PVAD GVEK KGEG TTTA EAAP ATGS KPDE PGKA GETP SEEK KGEG DAAT EQAA PQAP ASSE EKAG SAET ESAT KAST DNSP SSKA EDAP AKEE PKQA DVPA AVTA AAAT TPAA EDAA AKAT AQPP TETG ESSQ AEEN IEAV DETK PKES ARQD EGKE EEPE ADQE HA |
| Gene ID: | 2596 |
| Uniprot: | P17677 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasmic side, Peripheral membrane protein, filopodium membrane, growth cone membrane, synapse |
| Calculated MW: | 24kDa/28kDa |
| Observed MW: | Refer to figures |
 | Western blot - GAP43 Rabbit pAb (CAB16857) |
| Synonyms: | B-50, PP46, GAP43 |
| Background: | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: 3q13.31 Cellular Component: axon; cell junction; cytoplasm; filopodium membrane; plasma membrane; postsynaptic density Molecular Function:calmodulin binding; phosphatidylserine binding; protein binding Biological Process: axon choice point recognition; cell fate commitment; glial cell differentiation; protein kinase C activation; regulation of filopodium formation; regulation of growth; response to wounding; tissue regeneration |
| NCBI Summary: | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17677 |
| NCBI GenInfo Identifier: | 128100 |
| NCBI Gene ID: | 2596 |
| NCBI Accession: | P17677.1 |
| UniProt Secondary Accession: | P17677,A8K0Y4, |
| UniProt Related Accession: | P17677 |
| Molecular Weight: | |
| NCBI Full Name: | Neuromodulin |
| NCBI Synonym Full Names: | growth associated protein 43 |
| NCBI Official Symbol: | GAP43 |
| NCBI Official Synonym Symbols: | B-50; PP46 |
| NCBI Protein Information: | neuromodulin |
| UniProt Protein Name: | Neuromodulin |
| UniProt Synonym Protein Names: | Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46 |
| Protein Family: | Neuromodulin |
| UniProt Gene Name: | GAP43 |
| UniProt Entry Name: | NEUM_HUMAN |
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