Metabolism Antibodies 2
Anti-GALT Antibody (CAB6292)
- SKU:
- CAB6292
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-GALT Antibody |
| Antibody SKU: | CAB6292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-379 of human GALT (NP_000146.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, THP-1, HepG2, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-379 of human GALT (NP_000146.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRS GTDP QQRQ QASE ADAA AATF RAND HQHI RYNP LQDE WVLV SAHR MKRP WQGQ VEPQ LLKT VPRH DPLN PLCP GAIR ANGE VNPQ YDST FLFD NDFP ALQP DAPS PGPS DHPL FQAK SARG VCKV MCFH PWSD VTLP LMSV PEIR AVVD AWAS VTEE LGAQ YPWV QIFE NKGA MMGC SNPH PHCQ VWAS SFLP DIAQ REER SQQA YKSQ HGEP LLME YSRQ ELLR KERL VLTS EHWL VLVP FWAT WPYQ TLLL PRRH VRRL PELT PAER DDLA SIMK KLLT KYDN LFET SFPY SMGW HGAP TGSE AGAN WNHW QLHA HYYP PLLR SATV RKFM VGYE MLAQ AQRD LTPE QAAE RLRA LPEV HYHL GQKD RETA TIA |
| Gene ID: | 2592 |
| Uniprot: | P07902 |
| Cellular Location: | |
| Calculated MW: | 31kDa/43kDa |
| Observed MW: | 43kDa |
| Synonyms: | GALT |
| Background: | Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GALT: Defects in GALT are the cause of galactosemia (GALCT). Galactosemia is an inherited disorder of galactose metabolism that causes jaundice, cataracts, and mental retardation. Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.12; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Motility/polarity/chemotaxis; Transferase Chromosomal Location of Human Ortholog: 9p13 Cellular Component: cytosol; Golgi apparatus Molecular Function:protein binding; UDP-glucose:hexose-1-phosphate uridylyltransferase activity Biological Process: galactose catabolic process; galactose metabolic process Disease: Galactosemia |
| NCBI Summary: | Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P07902 |
| NCBI GenInfo Identifier: | 3183522 |
| NCBI Gene ID: | 2592 |
| NCBI Accession: | P07902.3 |
| UniProt Secondary Accession: | P07902,Q14355, Q14356, Q14357, Q14358, Q14359, Q14360 Q14361, Q14363, Q14364, B4E097, E7ET32, |
| UniProt Related Accession: | P07902 |
| Molecular Weight: | 31,107 Da |
| NCBI Full Name: | Galactose-1-phosphate uridylyltransferase |
| NCBI Synonym Full Names: | galactose-1-phosphate uridylyltransferase |
| NCBI Official Symbol: | GALT |
| NCBI Protein Information: | galactose-1-phosphate uridylyltransferase |
| UniProt Protein Name: | Galactose-1-phosphate uridylyltransferase |
| UniProt Synonym Protein Names: | UDP-glucose--hexose-1-phosphate uridylyltransferase |
| Protein Family: | Gallate transporter |
| UniProt Gene Name: | GALT |
| UniProt Entry Name: | GALT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GALT Rabbit pAb (CAB6292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using GALT antibody (CAB6292) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using GALT antibody (CAB6292) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using GALT antibody (CAB6292) at dilution of 1:100 (40x lens). |
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