Cell Biology Antibodies 5

FLCN Rabbit Polyclonal Antibody (CAB14521)

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SKU:
CAB14521
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
BHD, FLCL, DENND8B, FLCN
Research Use:
Cell Biology
Frequently bought together:

Description

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FLCN Antibody (CAB14521)

The FLCN Antibody (CAB14521) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications.FLCN is a tumor suppressor gene that is mutated in individuals with Birt-Hogg-Dubé syndrome, a rare genetic disorder characterized by the development of benign skin tumors, lung cysts, and kidney tumors. Research into the function of FLCN and its role in tumorigenesis is essential for understanding the molecular mechanisms underlying this syndrome and potentially identifying new therapeutic targets for cancer treatment.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:FLCN Antibody
SKU:CAB14521
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:RKLP VFKS LRHM RQVL GAPS FRML AWHV LMGN QVIW KSRD VDLV QSAF EVLR TMLP VGCV RIIP YSSQ YEEA YRCN FLGL SPHV QIPP HVLS SEFA VIVE VHAA ARST LHPV GCED DQSL SKYE FVVT SGSP VAAD RVGP TILN KIEA ALTN QNLS VDVV DQCL VCLK EEWM NKVK VLFK FTKV DSRP KEDT QKLL SILG ASEE DNVK LLKF WMTG LSKT YKSH LMST VRSP TASE SRN
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:BHD, FLCL, DENND8B, FLCN
Positive Sample:Mouse brain, Mouse thymus, Rat heart,
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:64kDa
Observed MW:70kDa

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID201163
RRIDAB_2761397
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using FLCN Rabbit pAb (CAB14521) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates / proteins: 25 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageImmunofluorescence analysis of C6 cells using FLCN Rabbit pAb (CAB14521) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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