Anti-FKBP51 Antibody [Hi51B]

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SKU:
STMA00021
Antibody Type:
Monoclonal
Applications:
WB
Applications:
ICC/IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Reactivity:
Rabbit
Reactivity:
Dog
Reactivity:
Hamster
Host Species:
Mouse
Isotype:
IgG1
  • Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B (STMA00021). Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody (STMA00021) at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Cells stained red. Courtesy of: the Hospital Henri Mondor, France.
  • Western Blot analysis of Human Cervical cancer cell line (HeLa) lysate showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B (STMA00021). Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody (STMA00021) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
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Description

FKBP51 Antibody [Hi51B]

FKBP51 Antibody [Hi51B] is a mouse monoclonal antibody directed against FKBP51, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse, Rat, Rabbit, Dog and Hamster. Supplied as IgG1, purified by Protein G.

FKBP51 (FK506-binding protein 5) is a co-chaperone of the Hsp90 complex and a key regulator of glucocorticoid receptor sensitivity, stress response, and protein folding. In the brain, FKBP51 modulates neuronal plasticity, inflammation, and tau protein stability—factors central to neurodegenerative disease progression. Elevated FKBP51 expression has been observed in Alzheimer’s disease and is associated with increased tau aggregation and impaired autophagy. Its role in stress hormone signaling also links FKBP51 to mood disorders and cognitive decline, making it a molecular bridge between chronic stress and neurodegeneration. Targeting FKBP51 offers a novel approach to modulate stress-related neurotoxicity and restore proteostasis in aging and diseased brains. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:FKBP51 Antibody [Hi51B]
Product SKU:STMA00021
Size:100 µg
Target:FKBP51
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:Hi51B
Research Areas:Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Nuclear Import/Export
Buffer:PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, ICC/IF
Antibody Isotype:IgG1
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Rabbit, Dog, Hamster
Recommended Dilution:WB (1:2000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~51kDa.
Guarantee:12 months from date of dispatch
Immunogen:Recombinant human FKBP51 fragment
Immunogen Species:Human
Accession Number:NP_001139247.1
Gene ID:2289
Swiss-Prot:Q13451
Cellular Localization:Cytoplasm | Nucleus
Alternative Names:AIG6, FK506 binding protein 5, FKBP5, FKBP54, HSP90 binding immunophilin, p54, Pplase, Ptg10, Rotamase, T cell FK506 binding protein
References:1. Cheung-Flynn J., Roberts P.J., Riggs D.L., and Smith D.F.(2003) J. Biol. Chem. 278(19): 17388-17394. 2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7): 4597-4600. 3. Wu B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101(22): 8348-8353. 4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146(7): 3194-3201. 5. Hubler T.R. et al. (2003) Endocrinology 144(6): 2380- 2387.
Note:For research use only.
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