Cell Death Antibodies 1

FHIT Rabbit Polyclonal Antibody (CAB1196)

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SKU:
CAB1196
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse
Synonyms:
FRA3B, AP3Aase, FHIT
Research Use:
Cell Death
Frequently bought together:

Description

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FHIT Antibody (CAB1196)

The FHIT Antibody (CAB1196) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.The FHIT gene plays a critical role in maintaining genomic stability and protecting against cancer development. Loss of FHIT expression has been associated with a poor prognosis in multiple cancer types, making it a promising target for cancer research and therapy development.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:FHIT Antibody
SKU:CAB1196
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LVNR KPVV PGHV LVCP LRPV ERFH DLRP DEVA DLFQ TTQR VGTV VEKH FHGT SLTF SMQD GPEA GQTV KHVH VHVL PRKA GDFH RNDS IYEE LQKH DKED FPAS WRSE EEMA AEAA ALRV YFQ
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:FRA3B, AP3Aase, FHIT
Positive Sample:A-549, HeLa, Jurkat, 293T, Mouse liver, Mouse kidney
Cellular Localization:Cytoplasm, Mitochondrion, Nucleus.
Calculated MW:17kDa
Observed MW:17kDa

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.

Purification MethodAffinity purification
Gene ID2272
RRIDAB_2758897
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using FHIT Rabbit pAb (CAB1196) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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