Epigenetics & Nuclear Signaling Antibodies 4

Anti-FANCA Antibody (CAB7671)

(No reviews yet) Write a Review
SKU:
CAB7671
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FANCA Antibody
Antibody SKU:CAB7671
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human FANCA (NP_000126.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human FANCA (NP_000126.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSDS WVPN SASG QDPG GRRR AWAE LLAG RVKR EKYN PERA QKLK ESAV RLLR SHQD LNAL LLEV EGPL CKKL SLSK VIDC DSSE AYAN HSSS FIGS ALQD QASR LGVP VGIL SAGM VASS VGQI CTAP AETS HPVL LTVE QRKK LSSL LEFA QYLL AHSM FSRL SFCQ ELWK IQSS LLLE AVWH LHVQ GIVS LQEL LESH PDMH AVGS WLFR NLCC LCEQ MEAS CQHA DVAR AMLS DFVQ MFVL RGFQ KNSD LRRT VEPE KMPQ VTVD VLQR MLI
Gene ID:2175
Uniprot:O15360
Cellular Location:Cytoplasm, Nucleus
Calculated MW:32kDa/159kDa/162kDa
Observed MW:163kDa
Synonyms:FANCA, FA, FA-H, FA1, FAA, FACA, FAH, FANCH
Background:The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.
UniProt Protein Function:FANCA: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCA are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA repair, damage

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: DNA repair; protein complex assembly

Disease: Fanconi Anemia, Complementation Group A; Tracheoesophageal Fistula With Or Without Esophageal Atresia

NCBI Summary:The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]
UniProt Code:O15360
NCBI GenInfo Identifier:147744560
NCBI Gene ID:2175
NCBI Accession:O15360.2
UniProt Secondary Accession:O15360,O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8 Q9UEL9, Q9UPK3, A5D923, B4DRI7, H3BSR5,
UniProt Related Accession:O15360
Molecular Weight:159,083 Da
NCBI Full Name:Fanconi anemia group A protein
NCBI Synonym Full Names:Fanconi anemia complementation group A
NCBI Official Symbol:FANCA  
NCBI Official Synonym Symbols:FA; FA1; FAA; FAH; FA-H; FACA; FANCH  
NCBI Protein Information:Fanconi anemia group A protein
UniProt Protein Name:Fanconi anemia group A protein
Protein Family:Fanconi anemia group A protein
UniProt Gene Name:FANCA  
UniProt Entry Name:FANCA_HUMAN
Anti-FANCA Antibody (CAB7671)Western blot analysis of extracts of HeLa cells, using FANCA antibody (CAB7671) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-FANCA Antibody (CAB7671)Immunohistochemistry of paraffin-embedded human stomach using FANCA antibody (CAB7671) at dilution of 1:100 (40x lens).
View AllClose

0 Reviews

View AllClose

Related Products

Human FANCA/FACA Recombinant Protein (RPES4368)

Human FANCA/FACA Recombinant Protein (RPES4368)

system_update_altDatasheetHuman FANCA/FACA Recombinant Protein FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia