Human FANCA/FACA Recombinant Protein (RPES4368)

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SKU:
RPES4368
Product Type:
Recombinant Protein
Species:
Human
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Description

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Human FANCA/FACA Recombinant Protein

FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.

Product Name:Human FANCA/FACA Recombinant Protein (RPES4368)
Product Code:RPES4368
Size:20µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:FA,FA-H,FA1,FAA,FACA,FAH,FANCH
Accession:AAH08979.1
Sequence:Met 1-Cys 297
Fusion tag:N-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human FANCA (AAH08979.1) (Met 1-Cys 297) was expressed, with a polyhistidine tag at the N-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:35.2 kDa
AP Mol Mass:35 kDa
Formulation:Lyophilized from sterile 20mM Tris, 200mM NaCl, pH 8.5, 20% gly, 0.1% Triton, 1mM TCEP
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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