Name: Anti-EXOSC10 Antibody (CAB17519)
Brand: Cell Biology Antibodies 13
SKU: CAB17519
Availability: OutOfStock

Antibody Name:	Anti-EXOSC10 Antibody
Antibody SKU:	CAB17519
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	A-549, Raji, Mouse testis, Mouse spleen, Mouse lung, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VAAG VKKS GPLP SAER LENV LFGP HDCS HAPP DGYP IIPT SGSV PVQK QASL FPDE KEDN LLGT TCLI ATAV ITLF NEPS AEDS KKGP LTVA QKKA QNIM ESFE NPFR MFLP SLGH RAPV SQAA KFDP STKI YEIS NRWK LAQV QVQK DSKE AVKK KAAE QTAA REQA KEAC KAAA EQAI SVRQ QVVL ENAA KKRE RATS DPRT TEQK QEKK RLKI SKKP KDPE PPEK EFTP YDYS QSDF KAFA GNSK SKVS SQFD PNKQ TPSG KKCI AAKK IKQS VGNK SMSF PTGK SDRG FRYN WPQR
Gene ID:	5394
Uniprot:	Q01780
Cellular Location:
Calculated MW:	98kDa/100kDa
Observed MW:	110kDa

Western blot - EXOSC10 Polyclonal Antibody (CAB17519)

Synonyms:	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
Background:

UniProt Protein Function:	EXOSC10: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Vesicle; Nucleolus; EC 3.1.13.- Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; exosome (RNase complex); nucleus; nuclear exosome (RNase complex) Molecular Function:protein binding; exoribonuclease activity; nucleotide binding; 3'-5' exonuclease activity Biological Process: RNA processing; maturation of 5.8S rRNA; dosage compensation, by inactivation of X chromosome; mRNA catabolic process, nonsense-mediated decay
UniProt Code:	Q01780
NCBI GenInfo Identifier:	8928564
NCBI Gene ID:	5394
NCBI Accession:	Q01780.2
UniProt Secondary Accession:	Q01780,Q15158, B1AKQ0, B1AKQ1,
UniProt Related Accession:	Q01780
Molecular Weight:	885
NCBI Full Name:	Exosome component 10
NCBI Synonym Full Names:	exosome component 10
NCBI Official Symbol:	EXOSC10
NCBI Official Synonym Symbols:	p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100
NCBI Protein Information:	exosome component 10; autoantigen PM-SCL; polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 100 kDa; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
UniProt Protein Name:	Exosome component 10
UniProt Synonym Protein Names:	Autoantigen PM/Scl 2; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; Polymyositis/scleroderma autoantigen 100 kDa; PM/Scl-100; Polymyositis/scleroderma autoantigen 2
Protein Family:	Exosome component
UniProt Gene Name:	EXOSC10
UniProt Entry Name:	EXOSX_HUMAN