Developmental Biology

EDARADD Rabbit Polyclonal Antibody (CAB15950)

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SKU:
CAB15950
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Synonyms:
CR, ED3, EDA3, ECTD11A, ECTD11B, EDARADD
Research Use:
Developmental Biology
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Description

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EDARADD Antibody (CAB15950)

The EDARADD Antibody (CAB15950) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the EDARADD protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in signal transduction and inflammation.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:EDARADD Antibody
SKU:CAB15950
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MGLR TTKQ MGRG TKAP GHQE DHMV KEPV EDTD PSTL SFNM SDKY PIQD TELP KAEE CDTI TLNC PRNS DMKN QGEE NGFP DSTG DPLP EISK DNSC KENC TCSS CLLR APTI SDLL NDQD LLDV IRIK LDPC HPTV KNWR NFAS KWGM SYDE LCFL EQRP QSPT LEFL LRNS QRTV GQLM ELCR LYHR ADVE KVLR RWVD EEWP KRER GDPS RHF
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CR, ED3, EDA3, ECTD11A, ECTD11B, EDARADD
Positive Sample:A-431, MCF7
Cellular Localization:Cytoplasm.
Calculated MW:25kDa
Observed MW:25kDa

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Purification MethodAffinity purification
Gene ID128178
RRIDAB_2763386
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using EDARADD Rabbit pAb (CAB15950) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
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