Anti-DUX4 Antibody [P2B1]

DUX4 Antibody [P2B1]

DUX4 Antibody [P2B1] is a mouse monoclonal antibody directed against DUX4, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human and Mouse. Supplied as IgG1, purified by Protein G.

DUX4 (Double Homeobox 4) is a transcription factor implicated in gene regulation during early development. In adult tissues, aberrant expression of DUX4 is associated with toxic gain-of-function effects, particularly in facioscapulohumeral muscular dystrophy (FSHD). Recent studies suggest that DUX4 may also contribute to neurodegenerative processes by activating stress response genes, disrupting RNA metabolism, and inducing apoptosis. Its expression in differentiated tissues, including skeletal muscle and potentially the nervous system, highlights its pathological relevance beyond muscular dystrophy. DUX4’s ability to modulate transcriptional networks and trigger cell death pathways positions it as a candidate for further investigation in neurodegeneration, especially in disorders involving epigenetic dysregulation and inflammatory signaling. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.