Anti-MDC1 Antibody [P2B11]

MDC1 Antibody [P2B11]

MDC1 Antibody [P2B11] is a mouse monoclonal antibody directed against MDC1, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse, Bovine and Chimpanzee. Supplied as IgG1, purified by Protein G.

Mediator of DNA Damage Checkpoint 1 (MDC1) is a key regulator of the DNA damage response (DDR), orchestrating the recruitment of repair proteins to sites of double-strand breaks. In post-mitotic neurons, where genomic integrity is critical for long-term function, MDC1 plays a vital role in maintaining neuronal viability. Dysregulation of MDC1 impairs DNA repair efficiency, contributing to the accumulation of DNA lesions observed in neurodegenerative diseases such as Alzheimer’s and Huntington’s disease. MDC1 also interacts with chromatin remodeling complexes and checkpoint kinases, linking it to broader epigenetic and cell cycle control mechanisms. As DNA damage and genomic instability are emerging hallmarks of neurodegeneration, MDC1 represents a promising target for therapeutic strategies aimed at enhancing neuronal resilience and genomic maintenance. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.