Cell Biology Antibodies 14

DUSP8 Rabbit Polyclonal Antibody (CAB17990)

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SKU:
CAB17990
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
HB5, HVH8, HVH-5, C11orf81, DUSP8
Research Use:
Cell Biology
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Description

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DUSP8 Antibody (CAB17990)

The DUSP8 Antibody (CAB17990) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and is ideal for use in Western blot applications. By binding specifically to the DUSP8 protein, this antibody enables the detection and analysis of DUSP8 in a variety of cell types, making it well-suited for research in the fields of cell signaling, cancer biology, and molecular biology.DUSP8, also known as MAP kinase phosphatase 5 (MKP-5), plays a crucial role in the control of MAP kinase signaling cascades, which are involved in numerous cellular processes such as proliferation, differentiation, and apoptosis.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DUSP8 Antibody
SKU:CAB17990
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:NleA GDRL PRKV Nl
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:1000 - 1:5000
IF/ICC1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HB5, HVH8, HVH-5, C11orf81, DUSP8
Positive Sample:Rat lung
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:66kDa
Observed MW:66kDa

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Purification MethodAffinity purification
Gene ID1850
RRIDAB_2861787
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Rat lung, using DUSP8 Rabbit pAb (CAB17990) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
Product ImageImmunofluorescence analysis of HeLa cells using DUSP8 Rabbit pAb (CAB17990) at dilution of 1:1000 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of NIH/3T3 cells using DUSP8 Rabbit pAb (CAB17990) at dilution of 1:1000 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of PC-12 cells using DUSP8 Rabbit pAb (CAB17990) at dilution of 1:1000 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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