KO Validated Antibodies 1

Anti-DPYSL2 Antibody (CAB14570)[KO Validated]

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SKU:
CAB14570
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-DPYSL2 Antibody [KO Validated]
Antibody SKU:CAB14570
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, U-251MG, 293T
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RIAV GSDA DLVI WDPD SVKT ISAK THNS SLEY NIFE GMEC RGSP LVVI SQGK IVLE DGTL HVTE GSGR YIPR KPFP DFVY KRIK ARSR LAEL RGVP RGLY D
Gene ID:1808
Uniprot:Q16555
Cellular Location:Cytoplasm, Membrane, cytoskeleton, cytosol
Calculated MW:58kDa/62kDa
Observed MW:62kDa
Synonyms:DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
Background:This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)).
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol

Molecular Function:protein binding; dihydropyrimidinase activity; protein kinase binding

Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

NCBI Summary:This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q16555
NCBI GenInfo Identifier:3122051
NCBI Gene ID:1808
NCBI Accession:Q16555.1
UniProt Secondary Accession:Q16555,O00424, A8K5H2, B4DR31, D3DSS7,
UniProt Related Accession:Q16555
Molecular Weight:
NCBI Full Name:Dihydropyrimidinase-related protein 2
NCBI Synonym Full Names:dihydropyrimidinase-like 2
NCBI Official Symbol:DPYSL2  
NCBI Official Synonym Symbols:DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2  
NCBI Protein Information:dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2
UniProt Protein Name:Dihydropyrimidinase-related protein 2
UniProt Synonym Protein Names:Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
Protein Family:Dihydropyrimidinase-related protein
UniProt Gene Name:DPYSL2  
UniProt Entry Name:DPYL2_HUMAN
Anti-DPYSL2 Antibody [KO Validated] (CAB14570)Western blot analysis of extracts of various cell lines, using DPYSL2 antibody (CAB14570) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-DPYSL2 Antibody [KO Validated] (CAB14570)Western blot analysis of extracts from normal (control) and DPYSL2 knockout (KO) HeLa cells, using DPYSL2 antibody (CAB14570) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-DPYSL2 Antibody [KO Validated] (CAB14570)Immunohistochemistry of paraffin-embedded rat brain using [KO Validated] DPYSL2 Rabbit pAb (CAB14570) at dilution of 1:400 (40x lens).
Anti-DPYSL2 Antibody [KO Validated] (CAB14570)Immunohistochemistry of paraffin-embedded mouse brain using [KO Validated] DPYSL2 Rabbit pAb (CAB14570) at dilution of 1:400 (40x lens).
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