DNA Polymerase gamma Rabbit Monoclonal Antibody (CAB1323)

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SKU:
CAB1323
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Reactivity:
Human, Mouse
Synonyms:
PEO, MDP1, SCAE, MIRAS, POLG1, POLGA, SANDO, MTDPS4A, MTDPS4B, DNA Polymerase gamma
Frequently bought together:

Description

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DNA Polymerase gamma Monoclonal Antibody (CAB1323)

The DNA Polymerase gamma Monoclonal Antibody (CAB1323) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications.DNA polymerase gamma is a key player in maintaining the integrity of mitochondrial DNA, making it critical for cellular energy production and overall mitochondrial function. Dysregulation of this enzyme has been implicated in various diseases, including mitochondrial disorders and certain types of cancer.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:DNA Polymerase gamma Monoclonal Antibody
SKU:CAB1323
Size:20μL, 100μL
Reactivity:Human, Mouse
Clone Number:ARC1871
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:LVRE EDRY RAAL ALQI TNLL TRCM FAYK LGLN DLPQ SVAF FSAV DIDR CLRK EVTM DCKT PSNP TGME RRYG IPQG EALD IYQI IELT KGSL EKRS QPGP
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PEO, MDP1, SCAE, MIRAS, POLG1, POLGA, SANDO, MTDPS4A, MTDPS4B, DNA Polymerase gamma
Positive Sample:HT-29, 293T, Mouse testis, Mouse brain
Cellular Localization:Mitochondrion, Mitochondrion Matrix, Mitochondrion Nucleoid.
Calculated MW:140kDa
Observed MW:140kDa

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Purification MethodAffinity purification
Gene ID5428
RRIDAB_2861682
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using DNA Polymerase gamma Rabbit mAb (CAB1323) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageWestern blot analysis of various lysates using DNA Polymerase gamma Rabbit mAb (CAB1323) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
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