Cell Cycle Antibodies 1

DMTF1 Rabbit Polyclonal Antibody (CAB17067)

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SKU:
CAB17067
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
Synonyms:
DMP1, DMTF, MRUL, hDMP1, DMTF1
Research Use:
Cell Cycle
Frequently bought together:

Description

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DMTF1 Antibody (CAB17067)

The DMTF1 Antibody (CAB17067) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly sensitive and specific for use in various research applications, including Western blotting and immunohistochemistry.DMTF1, also known as cyclin D binding Myb-like transcription factor 1, plays a crucial role in the control of cell cycle progression and cell fate determination. Its functions have been linked to various physiological processes, including embryonic development, tissue regeneration, and oncogenesis. By targeting DMTF1, researchers can gain insights into the molecular mechanisms underlying these processes and potentially discover novel therapeutic targets for cancer and other diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:DMTF1 Antibody
SKU:CAB17067
Size:20μL, 100μL
Reactivity:Human
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:VTVQ CHTP RVII QTVA TEDI TSSI SQAE LTVD SDIQ SSDF PEPP DALE ADTF PDEI HHPK MTVE PSFN DAHV SKFS DQNS TELM NSVM VRTE EEIS DTDL KQEE SPSD LASA YVTE GLES PTIE EQVD QTID DETI LIVP SPHG FIQA SDVI DTES VLPL TTLT DPIL QHHQ EESN IIGS SLGS PVSE DSKD VEDL VNCH
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DMP1, DMTF, MRUL, hDMP1, DMTF1
Positive Sample:HT-29
Cellular Localization:Cytosol, Nucleoplasm, Nucleus.
Calculated MW:84kDa
Observed MW:85kDa

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID9988
RRIDAB_2769187
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HT-29 cells, using DMTF1 Rabbit pAb (CAB17067) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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