Immunology Antibodies 2

DEFA1 Rabbit Polyclonal Antibody (CAB6897)

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SKU:
CAB6897
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse, Rat
Synonyms:
HP1, MRS, DEF1, HP-1, DEFA2, HNP-1, DEFA1
Research Use:
Immunology
Frequently bought together:

Description

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DEFA1 Antibody (CAB6897)

The DEFA1 Antibody (CAB6897) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in applications such as Western blotting.Defensin alpha 1 is known for its broad-spectrum antimicrobial activity, making it a key player in the body's defense against pathogens.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DEFA1 Antibody
SKU:CAB6897
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MRTL AILA AILL VALQ AQAE PLQA RADE VAAA PEQI AADI PEVV VSLA WDES LAPK HPGS RKNM ACYC RIPA CIAG ERRY GTCI YQGR LWAF CC
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HP1, MRS, DEF1, HP-1, DEFA2, HNP-1, DEFA1
Positive Sample:THP-1, U-937
Cellular Localization:Secreted.
Calculated MW:10kDa
Observed MW:10kDa

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Purification MethodAffinity purification
Gene ID1667
RRIDAB_2767456
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using DEFA1 Rabbit pAb (CAB6897) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
Product ImageImmunofluorescence analysis of Jurkat cells using DEFA1 Rabbit pAb (CAB6897) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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