Developmental Biology

DAB1 Rabbit Polyclonal Antibody (CAB10349)

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SKU:
CAB10349
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
SCA37, DAB1
Research Use:
Developmental Biology
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Description

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DAB1 Antibody (CAB10349)

The DAB1 Antibody (CAB10349) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards Disabled Homolog 1 in human samples, making it suitable for use in Western blotting and immunohistochemistry applications.Disabled Homolog 1, also referred to as DAB1, is a key player in neuronal development and synaptic plasticity, making it a compelling target for neuroscience and neurodevelopmental research.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DAB1 Antibody
SKU:CAB10349
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MSTE TELQ VAVK TSAK KDSR KKGQ DRSE ATLI KRFK GEGV RYKA KLIG IDEV SAAR GDKL CQDS MMKL KGVV AGAR SKGE HKQK IFLT ISFG GIKI FDEK TGAL QHHH AVHE ISYI AKDI TDHR AFGY VCGK EGNH RFVA IKTA QAAE PVIL DLRD LFQL IYEL KQRE ELEK KAQK DKQC EQAV Y
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:100 - 1:500
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SCA37, DAB1
Positive Sample:Mouse small intestine, Rat brain
Cellular Localization:Cytoplasm, Cytosol, Perinuclear Region Of Cytoplasm.
Calculated MW:64kDa
Observed MW:57kDa/59kDa

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.

Purification MethodAffinity purification
Gene ID1600
RRIDAB_2757894
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using DAB1 Rabbit pAb (CAB10349) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Product ImageImmunofluorescence analysis of SH-SY5Y cells using DAB1 Rabbit pAb (CAB10349) at dilution of 1:200 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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