Cell Biology Antibodies 2

Cathepsin L/V/K/H Rabbit Polyclonal Antibody (CAB12200)

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SKU:
CAB12200
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Rat
Synonyms:
MEP, CATL, CTSL1, Cathepsin L/V/K/H
Research Use:
Cell Biology
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Description

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Cathepsin L/V/K/H Antibody (CAB12200)

The Cathepsin L/V/K/H Antibody (CAB12200) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.Cathepsin L1 is known to play a key role in cancer progression, inflammation, and tissue remodeling, making it a promising target for therapeutic interventions in cancer and inflammatory diseases. By detecting and measuring the levels of Cathepsin L1 in different cell types, researchers can gain valuable insights into its function and potential as a biomarker or therapeutic target.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Rat samples.

Product Name:Cathepsin L/V/K/H Antibody
SKU:CAB12200
Size:20μL, 100μL
Reactivity:Human, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:APRS VDWR EKGY VTPV KNQG QCGS CWAF SATG ALEG QMFR KTGR LISL SEQN LVDC SGPQ GNEG CNGG LMDY AFQY VQDN GGLD SEES YPYE ATEE SCKY NPKY SVAN DTGF VDIP KQEK ALMK AVAT VGPI SVAI DAGH ESFL FYKE GIYF EPDC SSED MDHG VLVV GYGF ESTE SDNN KYWL VKNS WGEE WGMG GYVK MAKD RRNH CGIA SAAS YPTV
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MEP, CATL, CTSL1, Cathepsin L/V/K/H
Positive Sample:Rat kidney
Cellular Localization:Lysosome.
Calculated MW:38kDa
Observed MW:38kDa

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

Purification MethodAffinity purification
Gene ID1514
RRIDAB_2759082
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from LO2 cells, using Cathepsin L/V/K/H Rabbit pAb (CAB12200) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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