Cell Biology Antibodies 3

Cathepsin D Rabbit Polyclonal Antibody (CAB13292)

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SKU:
CAB13292
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
CPSD, CLN10, HEL-S-130P, Cathepsin D
Research Use:
Cell Biology
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Description

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Cathepsin D Antibody (CAB13292)

The Cathepsin D Antibody (CAB13292) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for recognizing CTSD in human samples and is ideal for use in Western blotting applications. By binding to CTSD, researchers can detect and study the expression of this protein in different cell types, making it beneficial for studies in areas such as cell biology, metabolism, and neurodegenerative diseases.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Cathepsin D Antibody
SKU:CAB13292
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LVRI PLHK FTSI RRTM SEVG GSVE DLIA KGPV SKYS QAVP AVTE GPIP EVLK NYMD AQYY GEIG IGTP PQCF TVVF DTGS SNLW VPSI HCKL LDIA CWIH HKYN SDKS STYV KNGT SFDI HYGS GSLS GYLS QDTV SVPC QSAS SASA LGGV KVER QVFG EATK QPGI TFIA AKFD GILG MAYP RISV NNVL PVFD NLMQ QKLV DQNI FSFY LSRD PDAQ PGGE LMLG G
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CPSD, CLN10, HEL-S-130P, Cathepsin D
Positive Sample:SK-BR-3, Rat lung
Cellular Localization:Lysosome, Melanosome, Secreted, Extracellular Space.
Calculated MW:45kDa
Observed MW:46kDa

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Purification MethodAffinity purification
Gene ID1509
RRIDAB_2760151
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from SK-BR-3 cells, using Cathepsin D Rabbit pAb (CAB13292) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageWestern blot analysis of lysates from Rat lung, using Cathepsin D Rabbit pAb (CAB13292) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human tonsil using Cathepsin D Rabbit pAb (CAB13292) at dilution of 1:20 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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