Cell Biology Antibodies 12

Anti-COX7A2 Antibody (CAB8406)

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SKU:
CAB8406
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COX7A2 Antibody
Antibody SKU:CAB8406
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-115 of human COX7A2 (NP_001856.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-115 of human COX7A2 (NP_001856.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLRN LLAL RQIG QRTI STAS RRHF KNKV PEKQ KLFQ EDDE IPLY LKGG VADA LLYR ATMI LTVG GTAY AIYE LAVA SFPK KQE
Gene ID:1347
Uniprot:P14406
Cellular Location:Mitochondrion inner membrane
Calculated MW:9kDa
Observed MW:11kDa
Synonyms:COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL
Background:Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14.
NCBI Summary:Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
UniProt Code:P14406
NCBI GenInfo Identifier:14249851
NCBI Gene ID:7286
NCBI Accession:BC008301
UniProt Secondary Accession:P14406,Q5T384, Q5T385, Q9BU28, Q9H5L1, B2RD57, D3DV21 D3DV22,
UniProt Related Accession:Q9NNX1
Molecular Weight:37,929 Da
NCBI Full Name:Homo sapiens tuftelin 1, mRNA
NCBI Synonym Full Names:tuftelin 1
NCBI Official Symbol:TUFT1  
NCBI Protein Information:tuftelin
UniProt Protein Name:Cytochrome c oxidase subunit 7A2, mitochondrial
UniProt Synonym Protein Names:Cytochrome c oxidase subunit VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIaL
Protein Family:Tuftelin
UniProt Gene Name:COX7A2  
UniProt Entry Name:CX7A2_HUMAN
Anti-COX7A2 Polyclonal Antibody (CAB8406)Western blot analysis of extracts of HeLa cells, using COX7A2 antibody (CAB8406) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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