Cell Biology Antibodies 10

COCH Rabbit Polyclonal Antibody (CAB6562)

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SKU:
CAB6562
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
DFNA9, COCH5B2, DFNB110, COCH-5B2, COCH
Research Use:
Cell Biology
Frequently bought together:

Description

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COCH Antibody (CAB6562)

The COCH Antibody (CAB6562) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Cochlin protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in the fields of neuroscience and otolaryngology.Cochlin, also known as COCH, is recognized for its roles in cochlear function and extracellular matrix organization within the inner ear.

This antibody is validated for use in IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:COCH Antibody
SKU:CAB6562
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:GPAG SEGA APIA ITCF TRGL DIRK EKAD VLCP GGCP LEEF SVYG NIVY ASVS SICG AAVH RGVI SNSG GPVR VYSL PGRE NYSS VDAN GIQS QMLS RWSA SFTV TKGK SSTQ EATG QAVS TAHP PTGK RLKK TPEK KTGN KDCK ADIA FLID GSFN IGQR RFNL QKNF VGKV ALML GIGT EGPH VGLV QASE HPKI EFYL KNFT SAKD VLFA IKEV GFRG GNSN TGKA LKHT AQKF FTVD A
Tested Applications:IHC-P IF/ICC ELISA
Recommended Dilution:
IHC-P1:50 - 1:100
IF/ICC1:50 - 1:100
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DFNA9, COCH5B2, DFNB110, COCH-5B2, COCH
Cellular Localization:Secreted, Extracellular Matrix, Extracellular Space.
Calculated MW:59kDa
Observed MW:RefertoFigures

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Purification MethodAffinity purification
Gene ID1690
RRIDAB_2767156
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human prostate using COCH Rabbit pAb (CAB6562) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunofluorescence analysis of HeLa cells using COCH Rabbit pAb (CAB6562). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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