Cell Biology Antibodies 10

Anti-COCH Antibody (CAB6562)

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SKU:
CAB6562
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COCH Antibody
Antibody SKU:CAB6562
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GPAG SEGA APIA ITCF TRGL DIRK EKAD VLCP GGCP LEEF SVYG NIVY ASVS SICG AAVH RGVI SNSG GPVR VYSL PGRE NYSS VDAN GIQS QMLS RWSA SFTV TKGK SSTQ EATG QAVS TAHP PTGK RLKK TPEK KTGN KDCK ADIA FLID GSFN IGQR RFNL QKNF VGKV ALML GIGT EGPH VGLV QASE HPKI EFYL KNFT SAKD VLFA IKEV GFRG GNSN TGKA LKHT AQKF FTVD A
Gene ID:1690
Uniprot:O43405
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:53kDa/59kDa
Observed MW:Refer to Figures
Synonyms:COCH, COCH-5B2, COCH5B2, DFNA9, cochlin
Background:The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
UniProt Protein Function:COCH: Plays a role in the control of cell shape and motility in the trabecular meshwork. Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9). DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Extracellular matrix

Chromosomal Location of Human Ortholog: 14q11.2-q13

Cellular Component: extracellular matrix

Molecular Function:collagen binding; protein binding

Biological Process: regulation of cell shape

Disease: Deafness, Autosomal Dominant 9

NCBI Summary:The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
UniProt Code:O43405
NCBI GenInfo Identifier:7387582
NCBI Gene ID:1690
NCBI Accession:O43405.1
UniProt Secondary Accession:O43405,Q96IU6, A8K9K9, D3DS84,
UniProt Related Accession:O43405
Molecular Weight:53,230 Da
NCBI Full Name:Cochlin
NCBI Synonym Full Names:cochlin
NCBI Official Symbol:COCH  
NCBI Official Synonym Symbols:DFNA9; COCH5B2; COCH-5B2  
NCBI Protein Information:cochlin
UniProt Protein Name:Cochlin
UniProt Synonym Protein Names:COCH-5B2
Protein Family:Cochlin
UniProt Gene Name:COCH  
UniProt Entry Name:COCH_HUMAN
Anti-COCH Antibody (CAB6562)Immunohistochemistry of paraffin-embedded human prostate using COCH antibody (CAB6562) at dilution of 1:100 (40x lens).
Anti-COCH Antibody (CAB6562)Immunofluorescence analysis of HeLa cells using COCH antibody (CAB6562). Blue: DAPI for nuclear staining.
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