Cell Biology Antibodies 3

CLDN11 Rabbit Polyclonal Antibody (CAB12478)

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SKU:
CAB12478
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
OSP, OTM, HLD22, CLDN11
Research Use:
Cell Biology
Frequently bought together:

Description

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CLDN11 Antibody (CAB12478)

The CLDN11 Antibody (CAB12478) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications including Western blot and immunohistochemistry.CLDN11 is essential for the formation and maintenance of tight junctions in the central nervous system, making it a key player in neurological diseases such as multiple sclerosis and brain tumors.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:CLDN11 Antibody
SKU:CAB12478
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MVAT CLQV VGFV TSFV GWIG VIVT TSTN DWVV TCGY TIPT CRKL DELG SKGL WADC VMAT GLYH CKPL VDIL ILPG YVQA CRAL MIAA SVLG LPAI LLLL
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:100
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:OSP, OTM, HLD22, CLDN11
Positive Sample:U-87MG, HepG2, SH-SY5Y, Mouse placenta
Cellular Localization:Cell Junction, Cell Membrane, Multi-Pass Membrane Protein, Tight Junction.
Calculated MW:22kDa
Observed MW:22kDa

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

Purification MethodAffinity purification
Gene ID5010
RRIDAB_2759321
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using CLDN11 Rabbit pAb (CAB12478) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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