Cell Biology Antibodies 6
Anti-CHRM1 Antibody (CAB1598)
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- SKU:
- CAB1598
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CHRM1 Antibody |
| Antibody SKU: | CAB1598 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CHRM1 (NP_000729.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HepG2 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CHRM1 (NP_000729.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WELG YWLC YVNS TINP MCYA LCNK AFRD TFRL LLLC RWDK RRWR KIPK RPGS VHRT PSRQ C |
| Gene ID: | 1128 |
| Uniprot: | P11229 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 50kDa/51kDa |
| Observed MW: | 51kDa |
| Synonyms: | CHRM1, HM1, M1, M1R |
| Background: | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. |
| UniProt Protein Function: | mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: membrane; plasma membrane; synapse Molecular Function:G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; positive regulation of cell proliferation; positive regulation of ion transport; protein kinase C activation; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic |
| NCBI Summary: | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11229 |
| NCBI GenInfo Identifier: | 113118 |
| NCBI Gene ID: | 1128 |
| NCBI Accession: | P11229.2 |
| UniProt Secondary Accession: | P11229,Q96RH1, |
| UniProt Related Accession: | P11229 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Muscarinic acetylcholine receptor M1 |
| NCBI Synonym Full Names: | cholinergic receptor muscarinic 1 |
| NCBI Official Symbol: | CHRM1 |
| NCBI Official Synonym Symbols: | M1; HM1; M1R |
| NCBI Protein Information: | muscarinic acetylcholine receptor M1 |
| UniProt Protein Name: | Muscarinic acetylcholine receptor M1 |
| Protein Family: | Muscarinic acetylcholine receptor |
| UniProt Gene Name: | CHRM1 |
 | Western blot analysis of extracts of various cell lines, using CHRM1 antibody (CAB1598) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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