Signal Transduction Antibodies 3

CFTR Rabbit Polyclonal Antibody (CAB8386)

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SKU:
CAB8386
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, CFTR
Frequently bought together:

Description

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CFTR Antibody (CAB8386)

The CFTR Antibody (CAB8386) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, shows high reactivity with CFTR in human samples and is validated for use in a variety of applications, including Western blot and immunofluorescence.CFTR is a key player in maintaining the balance of ions and water across cell membranes, particularly in the respiratory and digestive systems. Mutations in the CFTR gene lead to the development of Cystic Fibrosis, a genetic disorder characterized by thick mucus production and impaired organ function.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:CFTR Antibody
SKU:CAB8386
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:SILN PINS IRKF SIVQ KTPL QMNG IEED SDEP LERR LSLV PDSE QGEA ILPR ISVI STGP TLQA RRRQ SVLN LMTH SVNQ GQNI HRKT TAST RKVS LAPQ ANLT ELDI YSRR LSQE TGLE ISEE INEE DLKE CFFD DMES I
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, CFTR
Positive Sample:293T, Mouse testis, Rat testis
Cellular Localization:Cell Membrane, Early Endosome Membrane, Multi-Pass Membrane Protein.
Calculated MW:168kDa
Observed MW:168kDa

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.

Purification MethodAffinity purification
Gene ID1080
RRIDAB_2768875
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CFTR Rabbit pAb (CAB8386) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
Product ImageImmunofluorescence analysis of HT-29 cells using CFTR Rabbit pAb (CAB8386) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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