Signal Transduction Antibodies 3
Anti-CFTR Antibody (CAB8386)
- SKU:
- CAB8386
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Antibody Name: | Anti-CFTR Antibody |
| Antibody SKU: | CAB8386 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1161-1480 of human CFTR (NP_000483.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1161-1480 of human CFTR (NP_000483.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SRVF KFID MPTE GKPT KSTK PYKN GQLS KVMI IENS HVKK DDIW PSGG QMTV KDLT AKYT EGGN AILE NISF SISP GQRV GLLG RTGS GKST LLSA FLRL LNTE GEIQ IDGV SWDS ITLQ QWRK AFGV IPQK VFIF SGTF RKNL DPYE QWSD QEIW KVAD EVGL RSVI EQFP GKLD FVLV DGGC VLSH GHKQ LMCL ARSV LSKA KILL LDEP SAHL DPVT YQII RRTL KQAF ADCT VILC EHRI EAML ECQQ FLVI EENK VRQY DSIQ KLLN ERSL FRQA ISPS DRVK LFPH RNSS KCKS KPQI AALK EETE EEVQ DTRL |
| Gene ID: | 1080 |
| Uniprot: | P13569 |
| Cellular Location: | Cell membrane, Early endosome membrane, Multi-pass membrane protein |
| Calculated MW: | 69kDa/161kDa/168kDa |
| Observed MW: | 186kDa |
| Synonyms: | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 |
| Background: | This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. |
| UniProt Protein Function: | CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, chloride; Transporter, ABC family; Membrane protein, integral; Transporter; Hydrolase; EC 3.6.3.49 Chromosomal Location of Human Ortholog: 7q31.2 Cellular Component: recycling endosome; cell surface; cytoplasmic vesicle membrane; microvillus; protein complex; early endosome membrane; basolateral plasma membrane; apical plasma membrane; early endosome; cytoplasm; plasma membrane Molecular Function:bicarbonate transmembrane transporter activity; protein binding; chloride channel activity; enzyme binding; chloride channel inhibitor activity; chloride transmembrane transporter activity; channel-conductance-controlling ATPase activity; ATP-binding and phosphorylation-dependent chloride channel activity; ATP binding; PDZ domain binding Biological Process: intracellular pH elevation; response to drug; response to peptide hormone stimulus; cholesterol transport; iodide transport; transepithelial chloride transport; water transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; response to estrogen stimulus; bicarbonate transport; transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary |
| NCBI Summary: | This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13569 |
| NCBI GenInfo Identifier: | 90421313 |
| NCBI Gene ID: | 1080 |
| NCBI Accession: | NP_000483.3 |
| UniProt Secondary Accession: | P13569,Q20BG8, Q20BH2, Q2I0A1, Q2I102, |
| UniProt Related Accession: | P13569 |
| Molecular Weight: | 69,230 Da |
| NCBI Full Name: | cystic fibrosis transmembrane conductance regulator |
| NCBI Synonym Full Names: | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
| NCBI Official Symbol: | CFTRÂ Â |
| NCBI Official Synonym Symbols: | CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1Â Â |
| NCBI Protein Information: | cystic fibrosis transmembrane conductance regulator |
| UniProt Protein Name: | Cystic fibrosis transmembrane conductance regulator |
| UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel |
| Protein Family: | Cystic fibrosis transmembrane conductance regulator |
| UniProt Gene Name: | CFTRÂ Â |
| UniProt Entry Name: | CFTR_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using CFTR antibody (CAB8386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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