Epigenetics & Nuclear Signaling Antibodies 1
Anti-CDX2 Antibody (CAB0804)
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- SKU:
- CAB0804
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CDX2 Antibody |
| Antibody SKU: | CAB0804 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CDX2 (NP_001256.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, MCF7, Mouse small intestine, Mouse thymus, Rat small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CDX2 (NP_001256.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYVS YLLD KDVS MYPS SVRH SGGL NLAP QNFV SPPQ YPDY GGYH VAAA AAAA ANLD SAQS PGPS WPAA YGAP LRED WNGY APGG AAAA ANAV AHGL NGGS |
| Gene ID: | 1045 |
| Uniprot: | Q99626 |
| Cellular Location: | Nucleus |
| Calculated MW: | 33kDa |
| Observed MW: | 34kDa |
| Synonyms: | CDX2, CDX-3, CDX2/AS, CDX3 |
| Background: | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. |
| UniProt Protein Function: | CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: nucleoplasm; nucleus Molecular Function:transcription factor activity Biological Process: anterior/posterior axis specification; cell differentiation; negative regulation of transcription from RNA polymerase II promoter; organ morphogenesis; regulation of somitogenesis; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q99626 |
| NCBI GenInfo Identifier: | 311033469 |
| NCBI Gene ID: | 1045 |
| NCBI Accession: | Q99626.3 |
| UniProt Secondary Accession: | Q99626,O00503, Q5VTU7, Q969L8, Q9UD92, |
| UniProt Related Accession: | Q99626 |
| Molecular Weight: | 33,520 Da |
| NCBI Full Name: | Homeobox protein CDX-2 |
| NCBI Synonym Full Names: | caudal type homeobox 2 |
| NCBI Official Symbol: | CDX2 |
| NCBI Official Synonym Symbols: | CDX3; CDX-3; CDX2/AS |
| NCBI Protein Information: | homeobox protein CDX-2 |
| UniProt Protein Name: | Homeobox protein CDX-2 |
| UniProt Synonym Protein Names: | CDX-3; Caudal-type homeobox protein 2 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CDX2 |
| UniProt Entry Name: | CDX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDX2 antibody (CAB0804) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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