Antibody Name:	Anti-CD151 Antibody
Antibody SKU:	CAB1930
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 113-221 of human CD151 (NP_001034579.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse skeletal muscle

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 113-221 of human CD151 (NP_001034579.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	AYYQ QLNT ELKE NLKD TMTK RYHQ PGHE AVTS AVDQ LQQE FHCC GSNN SQDW RDSE WIRS QEAG GRVV PDSC CKTV VALC GQRD HASN IYKV EGGC ITKL ETFI QEHL R
Gene ID:	977
Uniprot:	P48509
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	28kDa
Observed MW:	28kDa

Synonyms:

CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24

Background:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.

UniProt Protein Function:	CD151: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD). NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. Belongs to the tetraspanin (TM4SF) family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; cytosol Molecular Function:integrin binding; protein binding Biological Process: T cell proliferation; cell migration; hemidesmosome assembly; extracellular matrix organization and biogenesis; cell adhesion Disease: Raph Blood Group System; Nephropathy With Pretibial Epidermolysis Bullosa And Deafness
NCBI Summary:	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P48509
NCBI GenInfo Identifier:	85687560
NCBI Gene ID:	977
NCBI Accession:	P48509.3
UniProt Secondary Accession:	P48509,Q14826, Q86U54, Q96TE3, A8KAK8, E9PI15,
UniProt Related Accession:	P48509
Molecular Weight:	253
NCBI Full Name:	CD151 antigen
NCBI Synonym Full Names:	CD151 molecule (Raph blood group)
NCBI Official Symbol:	CD151
NCBI Official Synonym Symbols:	GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24
NCBI Protein Information:	CD151 antigen; tspan-24; tetraspanin-24; membrane glycoprotein SFA-1; CD151 antigen (Raph blood group); hemidesmosomal tetraspanin CD151; platelet surface glycoprotein gp27; platelet-endothelial tetraspan antigen 3; platelet-endothelial cell tetraspan antigen 3
UniProt Protein Name:	CD151 antigen
UniProt Synonym Protein Names:	GP27; Membrane glycoprotein SFA-1; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD_antigen: CD151
Protein Family:	CD151 antigen
UniProt Gene Name:	CD151
UniProt Entry Name:	CD151_HUMAN

	Western blot analysis of extracts of mouse skeletal muscle, using CD151 Antibody (CAB1930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
	Immunohistochemistry of paraffin-embedded rat kidney using CD151 antibody (CAB1930) at dilution of 1:200 (40x lens).
	Immunohistochemistry of paraffin-embedded human lung cancer using CD151 antibody (CAB1930) at dilution of 1:200 (40x lens).