The CCR7 Monoclonal Antibody (CAB0121) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is suitable for use in various research applications, including immunohistochemistry, flow cytometry, and Western blotting.CCR7 plays a crucial role in the migration of immune cells to secondary lymphoid organs, where they can initiate immune responses and mount effective immune surveillance. Dysregulation of CCR7 expression or function has been implicated in a variety of diseases, including autoimmune disorders, inflammatory conditions, and certain cancers.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
CCR7 Monoclonal Antibody
SKU:
CAB0121
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0231
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
A-549, Jurkat, C6, Mouse lung, Mouse spleen, Rat lung
Cellular Localization:
Cell Membrane, Multi-Pass Membrane Protein.
Calculated MW:
43kDa
Observed MW:
43kDa
The protein encoded by this gene is a member of the G protein-coupled receptor family.This receptor was identified as a gene induced by the Epstein-Barr virus (EBV),and is thought to be a mediator of EBV effects on B lymphocytes.This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.It has been shown to control the migration of memory T cells to inflamed tissues,as well as stimulate dendritic cell maturation.The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.Signals mediated by this receptor regulate T cell homeostasis in lymph nodes,and may also function in the activation and polarization of T cells,and in chronic inflammation pathogenesis.Alternative splicing of this gene results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
1236
RRID
AB_2861452
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CCR7 Rabbit mAb (CAB0121) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
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