Epigenetics & Nuclear Signaling Antibodies 2
Anti-CBX8 Antibody (CAB6222)
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- SKU:
- CAB6222
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CBX8 Antibody |
| Antibody SKU: | CAB6222 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, 293T, HeLa, MCF-7, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human CBX8 (NP_065700.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLKA QAKA KAKT YEFR SDSA RGIR IPYP GRSP QDLA STSR AREG LRNM GLSP PASS TSTS STCR AEAP RDRD RDRD RDRE RDRE RERE RERE RERE RERE RGTS RVDD KPSS PGDS SKKR GPKP RKEL PDPS QRPL GEPS AGLG EYLK GRKL DDTP SGAG KFPA GHSV IQLA RRQD SDLV QCGV TSPS SAEA TGKL AVDT F |
| Gene ID: | 57332 |
| Uniprot: | Q9HC52 |
| Cellular Location: | Nucleus |
| Calculated MW: | 43kDa |
| Observed MW: | 50kDa |
| Synonyms: | CBX8, PC3, RC1 |
| Background: |
| UniProt Protein Function: | CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleoplasm; heterochromatin; nuclear chromatin; PcG protein complex; nucleus Molecular Function:protein binding; single-stranded RNA binding; ubiquitin-protein ligase activity; methylated histone residue binding Biological Process: transcription, DNA-dependent; histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q9HC52 |
| NCBI GenInfo Identifier: | 78099843 |
| NCBI Gene ID: | 57332 |
| NCBI Accession: | Q9HC52.3 |
| UniProt Secondary Accession: | Q9HC52,Q96H39, Q9NR07, |
| UniProt Related Accession: | Q9HC52 |
| Molecular Weight: | 389 |
| NCBI Full Name: | Chromobox protein homolog 8 |
| NCBI Synonym Full Names: | chromobox homolog 8 |
| NCBI Official Symbol: | CBX8 |
| NCBI Official Synonym Symbols: | PC3; RC1 |
| NCBI Protein Information: | chromobox protein homolog 8; polycomb 3; rectachrome 1; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila) |
| UniProt Protein Name: | Chromobox protein homolog 8 |
| UniProt Synonym Protein Names: | Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1 |
| Protein Family: | Chromobox protein |
| UniProt Gene Name: | CBX8 |
| UniProt Entry Name: | CBX8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CBX8 antibody (CAB6222) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat pancreas using CBX8 Antibody (CAB6222) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using CBX8 Antibody (CAB6222) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using CBX8 Antibody (CAB6222) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using CBX8 antibody (CAB6222). Blue: DAPI for nuclear staining. |
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