Signal Transduction Antibodies 3
Anti-CBLC Antibody (CAB7789)
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- SKU:
- CAB7789
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CBLC Antibody |
| Antibody SKU: | CAB7789 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-474 of human CBLC (NP_036248.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Raji, U-937, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-474 of human CBLC (NP_036248.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DEVQ ERLQ ACRD KPGS YIFR PSCT RLGQ WAIG YVSS DGSI LQTI PANK PLSQ VLLE GQKD GFYL YPDG KTHN PDLT ELGQ AEPQ QRIH VSEE QLQL YWAM DSTF ELCK ICAE SNKD VKIE PCGH LLCS CCLA AWQH SDSQ TCPF CRCE IKGW EAVS IYQF HGQA TAED SGNS SDQE GREL ELGQ VPLS APPL PPRP DLPP RKPR NAQP KVRL LKGN SPPA ALGP QDPA PA |
| Gene ID: | 23624 |
| Uniprot: | Q9ULV8 |
| Cellular Location: | |
| Calculated MW: | 47kDa/52kDa |
| Observed MW: | 52kDa |
| Synonyms: | CBLC, CBL-3, CBL-SL, RNF57 |
| Background: | This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: nucleus Molecular Function:signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination |
| NCBI Summary: | This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9ULV8 |
| NCBI GenInfo Identifier: | 125987803 |
| NCBI Gene ID: | 23624 |
| NCBI Accession: | Q9ULV8.3 |
| UniProt Related Accession: | Q9ULV8 |
| Molecular Weight: | ~ 52kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase CBL-C |
| NCBI Synonym Full Names: | Cbl proto-oncogene C |
| NCBI Official Symbol: | CBLC |
| NCBI Official Synonym Symbols: | CBL-3; RNF57; CBL-SL |
| NCBI Protein Information: | E3 ubiquitin-protein ligase CBL-C |
| UniProt Protein Name: | E3 ubiquitin-protein ligase CBL-C |
| UniProt Synonym Protein Names: | RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | CBLC |
| UniProt Entry Name: | CBLC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CBLC antibody (CAB7789) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using CBLC antibody (CAB7789). |
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